Aging Wrinkles

Wrinkles are creases or folds in the skin. In aging skin, they occur because of the loss of elasticity that accompanies aging and generalized loss of dermal thickness.

Even wrinkles are part of aging age alone is not the sole cause. Only "laugh lines" are a natural consequence of aging. These hairline depressions around the corners of the eye, as well as the deeper furrows between the nose and upper lip, probably occur because elastic fibers in the skin loosen over time, allowing the skin to sag and fold in on itself. Repeated muscle movement also causes furrows. Most of the rest of the lines in a "lived-in face" are a consequence of overexposure to ultraviolet (UV) sunlight, both UVA (responsible for tanning, wrinkling, and melanoma) and UVB (responsible for sunburn and basal and squamous cell carcinoma). UV light may damage skin by increasing the production of proteolytic enzymes that break down collagen, the connective tissue located beneath the dermis.

If aging, as some say, is a disease, then wrinkles can be viewed as small, improperly healed wounds. Indeed wrinkles are characterized by incorrect deposition of collagen and imperfect skin cell layering, which is also seen in healed wounds albeit on a much larger scale. If so, could the agents that modify the process of wound healing (by minimizing scar formation and improving skin remodeling) have a potential to prevent or even reduce wrinkles? Well, possibly. A good example of a wound-healing agent that appears to also have anti-wrinkle potential is the class of compounds called copper peptides.

There are three types of wrinkles:

Are the very fine wrinkles that happen in aging skin and they appear everywhere, not just in places that have been exposed to sunlight. Elastic fibers in your skin start to deteriorate around the age of 30, although you might not notice it until sometime later. This type of wrinkling happens even without sun exposure, but is probably heightened by it. 

Glyphic wrinkles
Are wrinkles that we all normally have, but which become accentuated with aging. If you have taken to wearing turtlenecks or scarves to hide those lines on your neck that didn't used to look so bad, you know what a glyphic wrinkle is. These tend to become more pronounced with muscle contraction or with facial expressions.

Furrows
Are those mostly straight lines that start to appear on the faces of aging people. Forehead lines, "crows" feet, laugh lines that go from the nose to the corner of your mouth, and just keep getting deeper...furrows. It is difficult to get rid of these types of wrinkles when they appear at rest between muscle groups. The "crow's feet" that remain visibly noticeable at the corners of your eyes even when you are not smiling, will probably not be eradicated, but may be reduced in appearance.

What exactly are copper peptides and how can they boost skin rejuvenation?

Generally speaking, peptides are small fragments of proteins. (And the proteins are the key building blocks of most living tissues.) Certain kinds of peptides have an avid affinity for copper, to which they bind very tightly. The resulting compound consisting of a peptide and a copper atom has become known as a copper peptide.

A lot of substances can have a positive effect on wound healing. A distinctive feature of GHK copper peptides is that they reduce scar tissue formation while stimulating normal skin remodeling. In other words, they help better restore the damaged area to its original look.

The mechanism of copper peptide action is relatively complex. GHK-Cu induces the degradation of "extra-large" collagen aggregates found in scars and promotes the synthesis of smaller more regular collagen found in normal skin. It also promotes the synthesis of elastin, proteoglycans, glycosaminoglycans and other components of skin matrix. Other important effects of GHK-Cu include the ability to regulate the growth rate and migration of different types of cells; significant anti-inflammatory action; and the ability to prevent the release of oxidation-promoting iron into the tissues. The net result is a faster, better and "cleaner" healing.

You might say it's nice to have cleanly healed wounds, but what about people who do not have any wounds or ulcerations to heal? Can copper peptides be useful for regular skin protection and rejuvenation? It appears that they can. However, while the wound healing effects of copper peptide have been investigated and documented in many studies, much less research has been done so far on their cosmetic and anti-aging use. The available evidence indicated the following potential skin benefits:

Many existing skin care treatments are based on the concept of removing the outermost or even deeper layers of the skin. The resulting healing process stimulates skin remodeling leading to smoother, younger looking skin. Since copper peptides optimize healing and improve skin remodeling, then can augment the effect of treatments based on various forms of controlled skin injury. In particular, copper peptides can be useful after various forms of laser resurfacing, dermabrasion, and chemical peels.

Copper peptides are effective against various forms of skin irritation, mainly due to their anti-inflammatory effects. Skin irritation, even in the absence of open lesions, dramatically accelerates skin aging by promoting the formation of free radicals and other toxic byproducts. Some common skin rejuvenation treatments, such as tretinoin (Retin A, Renova) and alpha hydroxy acids can cause irritation. If during treatment you experience skin irritation for an extended period of time, your skin will likely end up in a worse shape than when you started. In many cases, copper peptides can reduce or eliminate the irritation and help maximize treatment benefits.

It is always easier to prevent the damage than to fix it later. To a significant degree, skin aging is caused by the accumulation of minor day-to-day damage from sun, wind, detergents, acne, abrasions and so forth. As these minute lesions heal, they leave microscopic imperfections, which, eventually, accumulate to become visible signs of aging. While it remains to be further researched, it appears that copper peptide can help minimize the damage from daily wear and tear of the skin. For instance, one study demonstrated that copper peptides helped recover skin integrity after exposure to SLS, a common detergent found in many shampoos, cleansers, and dishwashing/laundry products.

It remains unclear whether copper peptides can reverse wrinkles and other signs of aging in the intact skin. Theoretically, it is possible since copper peptides promote the degradation of abnormally large cross-linked collagen (the one found in scars and, to a lesser degree, in wrinkles). They also stimulate the production of "regular" collagen found in normal skin. In one small study, copper peptides stimulated collagen production in the intact skin. In fact, in that study copper peptides produced a stronger stimulation of collagen synthesis than tretinoin (Retin A, Renova) or ascorbate (vitamin C).

While moderate use of copper peptides stimulates collagen synthesis and has antioxidant effect (by stimulating the antioxidant enzyme superoxide dismutase), excessive use can have an opposite effect by increasing the levels of free copper. Free copper promotes free radical damage and collagen breakdown leading to accelerated skin aging. These problems do not seem to occur among the majority of copper peptide users. However, there are anecdotal reports indicating that such side-effects might happen with overuse or, rarely, even normal use in sensitive individuals. Ideally, a sufficiently large study is needed to better quantify these risk.

Finally, copper peptides are a promising skin treatment with a good safety profile. Their ability to improve the healing of various types of skin lesions is well established. It is likely that copper peptides may slow down the development of the signs of skin aging by limiting the consequences of daily wear and tear. Also, copper peptides may augment the results of the skin rejuvenation treatments based on controlled skin injury, such as laser resurfacing, dermabrasion and peels. Also, it appears that copper peptides may cause rare but significant skin damaged in some cases of over use or unusual sensitivity.

What makes BIOSKINREPAIR ™ effective?

A natural cosmetic product, not a drug, pharmaceutical product. BIOSKINREPAIR ™ a natural product that can help your body regulates the levels of collagen.

BIOSKINREPAIR ™ its main component is the natural secretions from a Chilean land snail (Helix Aspersa Muller), the same they use to quickly repair their own skin and shell when damaged. It is a viscose liquid that is made into an odorless white cream with no alien or synthetic chemicals.

Analysis of the mucin has determined that it contains activators of skin growth factors and antimicrobial peptides, natural anti-inflammatory and immune modulating proteins, glycoproteins, glycosaminoglycans that tightly binds divalent captions, such as copper (II), and acharan sulfate glycosaminoglycan (GAG), as a protein-free polysaccharide.

Unlike harsh chemicals and physical processing typically used to produce protein supplements, which unfortunately denatures (destroys) the natural configuration of proteins yielding something that is not completely absorbed and utilized by the human body.

The topical application of BIOSKINREPAIR ™ under make-up is potent messages to your body that makes it react and indicate it keep the balance of elasticity and firming appearance altogether:

BIOSKINREPAIR ™ helps your skin moisturizer itself! There is nothing like it! It has been used on age lines, age spots, abrasions, acne, athlete's foot, boils, chilblains, diabetic sores, diaper rash, infected nails, insect bites/stings, skin allergies, skin ulcers and stretch marks and other skin problems and conditions. It is just excellent. Wounds heal with minimal scarring. Apply BIOSKINREPAIR ™ and get your skin rejuvenates again quickly and naturally!